Pluripotent stem cells that induce repair and regeneration after myocardial infarction

摘要

A cell preparation for use in the treatment of myocardial infarction, containing a cell fraction in which pluripotent SSEA-3 positive stem cells isolated from biological mesenchymal tissue or cultured mesenchymal cells have been concentrated, wherein the cell preparation is administered in a coronary artery or vein of a subject over 1 month after ischemia one to ten times in a therapeutically effective amount of 1 × 103 cells / individual to 1 × 106 cells / individual, or 1.7 × 105 to 2.5 × 105 cells / kg per individual and wherein said pluripotent stem cells have a plurality of properties, said plurality of properties comprising: (i) SSEA-3-positive; (ii) CD105-positive; (iii) low or absent telomerase activity; (iv) ability to differentiate into any of the three germ layers; (v) absence of demonstration of neoplastic proliferation; and (vi) capacity for self-renewal.