The present invention relates to a method of diagnosing and prognosing colorectal cancer using piRNA-hsa-5937, having the sequence TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA (SEQ ID NO. 1), as a biomarker. The biomarker can be combined with other piRNAs or miRNAs. The resulting method uses a body fluid as the input, and therefore is non-invasive, has a high sensitivity and specificity even in very early stages of the disease, and is cost-effective.
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机译：本发明涉及使用具有序列TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA（SEQ ID NO.1）的piRNA-hsa-5937作为生物标志物的大肠癌的诊断和预后方法。生物标志物可以与其他piRNA或miRNA组合。所得方法使用体液作为输入，因此是非侵入性的，即使在疾病的非常早期也具有高灵敏度和特异性，并且具有成本效益。
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