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Monoclonal antibody specific for the human Respiratory Syncytial Virus P protein and its use for the detection and diagnosis of RSV infection
Monoclonal antibody specific for the human Respiratory Syncytial Virus P protein and its use for the detection and diagnosis of RSV infection
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机译:对人呼吸道合胞病毒P蛋白具有特异性的单克隆抗体及其在RSV感染的检测和诊断中的用途
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摘要
The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. The invention provides also diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, comprising the antibodies produced by the mentioned hybridomas.
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机译:本发明涉及与人呼吸道合胞病毒(RSV)的蛋白P结合的单克隆抗体或其片段,其包含重链的可变区,该可变区的序列具有至少90%,95%或99的序列。与SEQ ID No:1或SEQ ID 5或具有与SEQ ID No:2或SEQ ID至少90%,95%或99%相同的序列的轻链可变区No:6。本发明还提供了离体或体外诊断RSV病毒抗原P的诊断方法,其中使用了由杂交瘤2E6 / D2和6H5 / H1产生和分泌的单克隆抗体。本发明可用于检测RSV试剂盒,所述试剂盒包含由所述杂交瘤产生的抗体。
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