MULTI-MODAL OPTICAL IMAGING SYSTEM FOR TISSUE ANALYSIS

摘要

A modular system for organic sample analysis is disclosed whichincludes a sample stage including a support platform and a motorizedpositioning mechanism mounted on the support platform, and a sample holdermounted on the motorized positioning mechanism upon which a sample isplaced. A probe support rack is mounted on the support platform and two ormore bio-imaging probes mounted on the probe support and arranged in apredefined geometry with respect to each other, and at least one bio-imagingprobe hays a field of view independent of all other bio-imaging probes. Thesystem includes a computer controller connected to the motorized positioningmechanism and the two or more bio-imaging probes. The computer isprogrammed for controlling motorized positioning mechanism to move thesample holder having the sample located thereon to positions in the field ofview of each bio-imaging probe where the sample can be analyzed individuallyby each of the bio-imaging probes. The computer includes a storage mediumfor storing an imaging data from each bio-imaging probe. The computer isprogrammed for spatially correlating imaging data of the selected volume ofinterest with the imaging data obtained from at least one other bio-imagingprobe and storing the spatially correlated imaging data in the computerstoragemedium.