PRODUCTS AND METHODS FOR THE DETECTION OF PATHOGENIC ANITBODIES IN HEPARIN-INDUCED THROMBOCYTOPENIA

摘要

Described are mutant Platelet Factor 4 (PF4) proteins that exhibit differentbinding affinities to pathogenic platelet-activating heparin-inducedthrombocytopenia (HIT) antibodies relative to non-pathogenic anti-PF4/heparinantibodies that are not platelet activating. The mutant PF4proteins may be used in an immunoassay for the detection of pathogenic HITantibodies and/or for classifying a subject as having an increased ordecreased risk of HIT.