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STABLE PHARMACEUTICAL COMPOSITIONS OF DPP-IV INHIBITORS IN COMBINATION WITH METFORMIN IN THE FORM OF IMMEDIATE RELEASE TABLETS
STABLE PHARMACEUTICAL COMPOSITIONS OF DPP-IV INHIBITORS IN COMBINATION WITH METFORMIN IN THE FORM OF IMMEDIATE RELEASE TABLETS
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机译:立即发布片剂形式的DPP-IV抑制剂与二甲双胍联用的稳定药物成分
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摘要
The present invention relates to stable immediate release tablets, comprising metformin and a DPP-IV inhibitor comprising at least a granulated portion which was granulated prior to its incorporation into a tablet and at least a second portion, wherein the granulated portion comprises metformin or a pharmaceutically acceptable salt thereof, an amount of water below 5 wt% relative to the weight of the granulated portion, and optionally a binder, and wherein the second portion comprises vildagliptin or a pharmaceutically acceptable salt thereof, a diluent, a disintegrating agent and a lubricant.
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