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ADOPTIVE T-CELL THERAPY FOR CMV INFECTION AND CMV-ASSOCIATED DISEASES
ADOPTIVE T-CELL THERAPY FOR CMV INFECTION AND CMV-ASSOCIATED DISEASES
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机译:CMV感染和CMV相关疾病的适应性T细胞治疗
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摘要
Provided herein are immunogenic polypeptides, compositions, and methods related to the development of CMV-specific prophylactic and/or therapeutic immunotherapy based on T cell epitopes (e.g., CMV epitopes) that are recognized by cytotoxic T cells (CTLs) and can be employed in the prevention and/or treatment of CMV infection, reactivation, and/or disease (e.g., CMV-associated end organ disease), especially in solid organ transplant recipients.
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