METHOD FOR SOLUTION-PHASE PEPTIDE SYNTHESIS AND PROTECTING STRATEGIES THEREFORE

摘要

The disclosed invention relates generally to the field of peptide synthesis. A novel method of solution-phase peptide synthesis is disclosed that utilizes novel group-assisted purification protecting groups to facilitate efficient, scalable chemistry to synthetically manufacture peptides. The disclosed invention addresses failings in the art by drastically reducing waste, increasing scalability, and affording high crude purities to largely avoid post- synthesis purification.