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A RODENT MODEL OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
A RODENT MODEL OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
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机译:骨质疏松症的啮齿动物模型
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摘要
A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in antisense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.
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