COMPOSITIONS AND METHODS FOR REDUCTION OF LIPOPROTEIN A FORMATION AND TREATMENT OF AORTIC VALVE SCLEROSIS AND AORTIC STENOSIS

摘要

Compositions and methods to reduce the formation of lipoprotein(a) are provided, thereby reducing the risk of aortic stenosis or aortic valve sclerosis. Antibodies or antigen-binding fragments thereof capable of binding apolipoprotein B₁₀₀ or apolipoprotein a are provided, which effectively prevents the binding and assembly of lipoprotein(a), thereby reducing the risk of aortic valve stenosis or sclerosis.