A SYSTEM AND A METHOD FOR PREDICTING THE OUTCOME OF BARIATRIC SURGERY BASED ON MICROBIOME COMPOSITION

摘要

The present invention provides methods for predicting post-operative body mass index (BMI) loss in a subject candidate for bariatric surgery as well as likelihood of success of such surgery, comprising obtaining from a subject candidate for bariatric surgery gut microbiome composition of said subject; and predicting the post-operative BMI loss of said subject by applying to the microbiome composition of said subject a pre-defined model developed by a machine learning algorithm based on a linear classifier and calculated from pre-operative and post-operative BMI and pre-operative gut microbiome composition of reference individuals that previously underwent bariatric surgery. The present invention further provides methods for treating obesity in a subject by predicting post-operative BMI loss of a subject candidate as described above, and treating the subject based on the predicted BMI loss by performing a bariatric surgery.