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HIGH RESOLUTION DETECTION OF DNA ABASIC SITES
HIGH RESOLUTION DETECTION OF DNA ABASIC SITES
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机译:DNA碱基的高分辨率检测
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摘要
The present invention provides method of labelling a nucleic acid containing an abasic (AP) site. The method includes the step of reacting a nucleic acid comprising an AP site with an aldehyde probe, such that the probe covalently binds to the AP site to produce a nucleic acid labelled with the probe; optionally oxidising the nucleic acid labelled with the probe; optionally isolating the labelled nucleic acid, and selectively cleaving the nucleic acid at the AP site to produce nucleic acid fragments.
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