ANTIBODY-COUPLED T CELL RECEPTORS (ACTRs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF

摘要

Disclosed herein are genetically engineered hematopoietic cells (e.g., genetically engineered hematopoietic stem cells, or genetically engineered immune cells), which co¬ express one or more co- stimulatory polypeptides with an antibody-coupled T cell receptor (ACTR), and uses thereof for enhancing antibody-dependent cell cytotoxicity (ADCC) in a subject in need of the treatment.