PROGRAMMABLE DESIGNER THERAPEUTIC FUSOGENIC SECRETED GECTOSOME VESICLES FOR MACROMOLECULE DELIVERY AND GENOME MODIFICATION

摘要

The invention includes systems, methods, and compositions for designing secreted fusogenic ectosome vesicles, or gectosomes, that selectively encapsulate specific target proteins, nucleic acids and/or other small molecules in a predetermined manner. These engineered gectosomes can be used to deliver desired cargos to receipt cells in vitro, ex vivo, or in vivo and may further reprogram target cellular phenotypes in a dose-dependent manner, as well as perform genome editing functions among others.