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FLOW CELLS WITH STABLE POLYMER COATING AND THEIR USES FOR GENE SEQUENCING
FLOW CELLS WITH STABLE POLYMER COATING AND THEIR USES FOR GENE SEQUENCING
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机译:具有稳定聚合物涂层的流通池及其在基因测序中的用途
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摘要
A flow cell article is provided where the flow cell article includes a substrate having one or more layers; a fluidic channel disposed in the substrate wherein the fluidic channel includes at least one reactive surface comprising: a coupling agent having a first functional group covalently attached to the substrate of the fluidic channel and a second imide functional group covalently attached to a polymer of formula (I), where R1 is a residue of an unsaturated monomer that has been copolymerized with maleic anhydride; R2 is H, an alkyl group, an oligo(ethylene glycol), and/or a dialkyl amine; m, n, and o are each from 1 to 10,000; X is a divalent NH, O, and/or S; and Z is the first functional group.
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机译:提供了一种流动池制品,其中该流动池制品包括具有一层或多层的基底;和设置在基材中的流体通道,其中所述流体通道包括至少一个反应性表面,所述反应性表面包括:偶联剂,所述偶联剂具有共价连接至所述流体通道的基材的第一官能团和共价连接至式(II)的聚合物的第二酰亚胺官能团I),其中R 1 Sub>是已经与马来酸酐共聚的不饱和单体的残基; R 2 Sub>为H,烷基,低聚(乙二醇)和/或二烷基胺; m,n和o分别为1至10,000; X是二价NH,O和/或S; Z是第一个官能团。
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