FLUORESCENT PROBE FOR DETECTING NAD(P)H IN MITOCHONDRIA, AND DETECTION METHOD USING SAME

摘要

The present invention relates to a fluorescent probe for detecting NAD(P)H in mitochondria, and a detection method using same. A probe of the present invention exhibits high selectivity and sensitivity to NAD(P)H and emits strong red fluorescence in the presence of NAD(P)H. Therefore, the probe exhibits predominant accumulation in the mitochondria of living cells, is usable in the detection and quantification of NAD(P)H in the mitochondria, and can provide a selective image of the mitochondria in real time, thereby being effectively usable for biological pathway studies and the identification of pathological diagnoses and the like. In addition, the present invention can be used to differentiate cancer cells from normal cells on the basis of mapping of the intensity of NAD(P)H-dependent fluorescence in mitochondria.