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STAPLED PEPTIDES AS PYRIN-DOMAIN TARGETED NLRP3 INFLAMMASOME INHIBITORS
STAPLED PEPTIDES AS PYRIN-DOMAIN TARGETED NLRP3 INFLAMMASOME INHIBITORS
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机译:斑肽作为吡喃-靶向的NLRP3炎症抑制剂
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摘要
Peptides useful as inflammasome inhibitors are disclosed and can comprise an H2 helix of a pyrin domain, wherein at least two non-consecutive amino acids of the H2 helix are covalently linked. Methods of treating a subject with a disease comprising administering to the subject the disclosed peptides are also disclosed. Further, disclosed herein are methods of inhibiting binding between a first polypeptide comprising a pyrin domain and a second polypeptide comprising a pyrin domain, the method comprising contacting either the first polypeptide or the second polypeptide with the disclosed peptides.
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