STEM-LOOP RECEPTOR-BASED FIELD-EFFECT TRANSISTOR SENSOR DEVICES TARGET DETECTION FOR SMALL-MOLECULE UNDER PHYSIOLOGICAL SALT CONCENTRATIONS

摘要

Devices for detecting at least one target molecule in a sample are provided. The devices comprise a field-effect transistor and an aptamer attached to the field-effect transistor. The aptamer comprises a capture region and a stem region, wherein the target molecule can selectively bind to the capture region of the aptamer. The stem region can change a conformation of the aptamer when the capture region binds to the target molecule. Techniques for detecting a target molecule using such devices are also provided.