CELL AGGREGATION INCLUDING OLFACTORY NEURON OR PRECURSOR CELL THEREOF, AND METHOD FOR PRODUCING SAME

摘要

A method for producing a cell cluster including an olfactory neuron or a precursor cell thereof, including the following steps (1) through (3): a step (1) for suspension-culturing pluripotent stem cells in the presence of a first Wnt signaling pathway inhibitor and forming a cell aggregate; a step (2) for suspension-culturing the cell aggregate obtained in step (1) in the presence of a BMP signaling pathway agonist; and a step (3) for suspension-culturing the cell aggregate obtained in step (2) and obtaining a cell cluster, the step (3) including at least one step selected from the group consisting of a step (3a) for suspension culturing in the presence of an FGF signaling pathway agonist, a step (3b) for suspension culturing in the presence of a BMP signaling pathway inhibitor, and a step (3c) for culturing in the presence of an FGF signaling pathway agonist and a BMP signaling pathway inhibitor.