SINGLE CELLULAR DIAGNOSIS OF PRIMARY VITREORETINAL LYMPHOMA

摘要

This invention relates to a methodology for single cell-based analysis of vitreous aspiration samples for diagnosis of vitreoretinal lymphoma (PVRL) such as primary vitreoretinal lymphoma (PVRL). Analysis of clonality, copy number aberration, BCL2/JH (t14;18) translocation and/or MYD88 mutations are performed on whole genomic amplified DNA derived from single B-cells to provide molecular-based diagnosis of VRL, which cannot be achieved by conventional cytology diagnosis approach.