NEW CRYSTAL FORM OF DPP-IV INHIBITOR HYPOGLYCEMIC DRUG AND PREPARATION METHOD THEREOF

摘要

Disclosed is a new crystal form F of a DPP-IV inhibitor hypoglycemic drug, (8-[(3R)-3-aminopiperidine-1-yl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methylquinazoline-2-yl)methyl]-1H-purine-2,6-dione), and a preparation method thereof. The X-ray powder diffraction pattern of the crystal form F includes 3 or more 2θ values selected from the following group: 12.8±0.2°, 14.6±0.2°, 16.8±0.2°, 17.5±0.2° and 18.1±0.2°, and the differential scanning calorimetry spectra of the crystal form F has endothermic peaks at 80-110°C, 120-135°C, 167-172°C and 203-209°C. The crystal form F has the advantages of stable physical and chemical properties, high purity, simple preparation method, and suitability for large-scale industrial production.