Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors

摘要

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer. (Figure (I))