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Design and Synthesis of Pyrrolidine-Based Nucleotide Mimetics for Use as Inhibitors of the DNA Repair Enzyme AAG

机译：吡咯烷基核苷酸模拟物的设计与合成用作DNA修复酶AAG的抑制剂

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作者
Mas Claret, Eduard.;
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作者单位

University of Surrey (United Kingdom).;

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授予单位 University of Surrey (United Kingdom).;
学科
学位 Ph.D.
年度 2018
页码 273 p.
总页数 273
原文格式 PDF
正文语种 eng
中图分类 AAI11010142;
关键词
DNA repair;

机译：DNA修复;

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专利

1. Specific Binding of the DNA Repair Enzyme AlkA to a Pyrrolidine-Based Inhibitor [J] . Orlando D. Schaerer, Jean-Yves Ortholand, A. Ganesan, Journal of the American Chemical Society . 1995,第24期

机译：DNA修复酶AlkA与基于吡咯烷的抑制剂的特异性结合。
2. An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG) [J] . Claret Eduard Mas, Al Yahyaei Balqees, Chu Shuyu, The Journal of the American Academy of Orthopaedic Surgeons . 2020,第11期

机译：DNA修复酶烷基糖基糖酶（AAG）的AZA-核苷，片段状抑制剂
3. An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG) [J] . Claret Eduard Mas, Al Yahyaei Balqees, Chu Shuyu, Bioorganic and medicinal chemistry . 2020,第11期

机译：DNA修复酶烷基糖基糖酶（AAG）的AZA-核苷，片段状抑制剂
4. DESIGN and synthesis of a new class of fluorescent photoaffinity label with specific reference to 4-benzoyl-1-benzamidofluorescein, a new photolabel for adenine nucleotide biding domains on enzymes [C] . Jane E. Rosen Fluorescence Science and Technology . 2000

机译：设计和合成具有特定参考4-苯甲酰-1-苯胺氟荧光素的新类荧光光化酶标签，一种新的光致吲哚氏蛋白弯曲域对酶的新型光洛标签
5. Design and Synthesis of Triazole-Based Inhibitors of the DNA Repair Enzyme Alkyladenine Glycosylase (AAG) [D] . Al Yahyaei, Balqees. 2018

机译：DNA修复酶烷基腺苷糖基酶（AAG）的三唑基抑制剂的设计与合成
6. Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis structural and functional characterisation [O] . Fadi Soukarieh, Matthew W. Nowicki, Amandine Bastide, -1

机译：设计翻译起始因子eIF4E的核苷酸模拟和非核苷酸抑制剂：合成结构和功能表征
7. Design and Synthesis of a Trifunctional Molecular System Programmed to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells [O] . -1

机译：设计和合成为阻断表皮生长因子受体酪氨酸激酶的三官能分子系统，诱导高水平的DNA损伤，并抑制前列腺癌细胞中的DNA修复酶（聚（ADP-核糖）聚合酶）

Design and Synthesis of Pyrrolidine-Based Nucleotide Mimetics for Use as Inhibitors of the DNA Repair Enzyme AAG

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