METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HIDRADENITIS SUPPURATIVA IN PATIENTS IN NEED THEREOF

摘要

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating, disease of the skin that usually presents after puberty. It features painful, deep-seated, inflamed lesions most commonly in the axillary, inguinal and anogenital regions. The inventors report a successful HS treatment with a calcium channel blocker: verapamil. Compared to biologic agents, verapamil is safer and cheaper. Given its possible role on TNF-α/IL-1, calcium channel blockers thus represent an alternative therapeutic option in mild and moderate HS. Accordingly, the present invention relates to a method of treating Hidradenitis suppurativa in a patient in need thereof comprising administering to the subject a therapeutically effective amount of a calcium-channel blocker.