A METHOD TO DETERMINE IF A CIRCULATING FETAL CELL ISOLATED FROM A PREGNANT MOTHER IS FROM EITHER THE CURRENT OR A HISTORICAL PREGNANCY

摘要

Disclosed are methods for determining a genetic origin of fetal cellular DNA obtained from a pregnant female who is carrying a fetus in a current pregnancy. Methods are also disclosed for using the fetal cellular DNA and fetal cell-free DNA (cfDNA) to determine fetal genetic conditions such as copy number variations. The methods disclosed uses a probabilistic model to determine fetal cellular DNA origin based on alleles observed at informative genetic marker of the fetal cellular DNA. Systems and computer program products for performing the methods are also disclosed.