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FORCE - DEPENDENT DRUG RELEASE SYSTEM TO ENHANCE SELECTIVE KILLING AND MINIMIZE ADVERSE EFFECTS IN CANCER TREATMENT
FORCE - DEPENDENT DRUG RELEASE SYSTEM TO ENHANCE SELECTIVE KILLING AND MINIMIZE ADVERSE EFFECTS IN CANCER TREATMENT
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机译:依赖药物释放的系统可以增强选择性杀伤并减少癌症治疗中的不利影响。
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摘要
The disclosure provides a force-dependent drug release system. The system is configured such that the drug is only released and subsequently internalized by cancer cells, which exert at least a threshold amount of force on a DNA component of the system. The system includes a tension sensor that is used to release a chemotherapeutic agent selectively into cancer cells. The system includes a first nucleic acid single strand of DNA or DNA analog that is conjugated to a substrate, and a second nucleic acid single strand of DNA or DNA analog that is hybridized to the first single strand. The second single strand is conjugated to a cytotoxic molecule that includes a cell surface receptor ligand and a chemotherapeutic agent. The second single strand is not conjugated to the substrate. Also provided are cancer cells that display a surface receptor ligand that is bound to the cytotoxic molecule. Also provided are one or more cancer cells that have internalized a single strand conjugated to the cytotoxic molecule, but have not internalized the first strand. Also provided are methods of treating cancer by administering the system The disclosure also provides a method for treating cancer by administering to an individual in need thereof. Also provided is a method for screening or testing chemotherpeutic agents for use in the system.
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