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Quickly disintegrating foam wafer with high mass per unit area
Quickly disintegrating foam wafer with high mass per unit area
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机译:快速崩解泡沫片,单位面积质量高
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摘要
The invention relates to flat dosage forms that disintegrate or dissolve in an aqueous environment for releasing at least one active ingredient in a body orifice or body cavity, and which are formed from a polymer matrix in the form of a solidified foam having cavities, and at least one pharmaceutical active ingredient, and which have a high mass per unit area in the region of 50 to 350 g/m². Despite their high mass per unit area and the resulting high active ingredient loading during administration, these dosage forms are characterised by a substantially improved mouthfeel in comparison to conventional film dosage forms. The invention also relates to methods for producing a dosage form of this type.
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机译:本发明涉及在水性环境中崩解或溶解以在体孔或体腔中释放至少一种活性成分的扁平剂型,其由具有空腔的固化泡沫形式的聚合物基质形成,并在至少一种药物活性成分,并且每单位面积的质量较高,约为50至350 g /m²。尽管它们的单位面积质量高并且在给药过程中产生高的活性成分负载,但是与常规的薄膜剂型相比,这些剂型的特征是口感明显改善。本发明还涉及制备这种剂型的方法。
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