Recombinant oncolytic viruses for treatment of metastatic cancers

摘要

Disclosed are recombinant oncolytic viruses that express one or more reovirus fusion-associated small transmembrane (FAST) proteins and uses thereof. The oncolytic activity of the recombinant oncolytic viruses expressing FAST proteins can be used to treat primary and metastatic cancers, especially from breast and colon cancers.