Method for fabricating integrated model of flexible human esophagus, stomach, duodenum, and small intestine, and dynamic in vitro biomimetic digestive system thereof

摘要

Provided are a method for fabricating an integrated model of a flexible human esophagus, stomach, duodenum, and small intestine, and a dynamic in vitro biomimetic digestive system thereof. The method for preparation comprises scanning the internal and external structures of a human esophagus, stomach, duodenum, and small intestine to obtain a corresponding mold; applying a mold release agent evenly on the mold; pouring an elastic liquid material into the mold; waiting for same to cure, then releasing from the mold to separately obtain an esophagus model (a), stomach model (b), duodenum model (c), and small intestine model (d); cleaning the surfaces of same, then air-drying; using an adhesive to bond together, in sequence, the esophagus model (a), stomach model (b), duodenum model (c), and small intestine model (d) to obtain an integrated model; by means of a peristaltic pressing apparatus, applying pressure to the two sides of each of the esophagus model (a), stomach model (b), and duodenum model (c) to achieve biomimetic motion. It is thus possible to simulate the process of digestion of the human stomach and duodenum, providing accurate experimental data for research on the human digestive system while also appropriately reducing experimentation on animals and humans.