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Novel platforms for co-stimulation, novel car designs and other enhancements for adoptive cellular therapy
Novel platforms for co-stimulation, novel car designs and other enhancements for adoptive cellular therapy
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机译:用于共同刺激的新颖平台,新颖的汽车设计以及过继细胞疗法的其他增强功能
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摘要
The disclosure provides compositions and method that promote adoptive cellular therapy. The disclosure provides polynucleotides, vectors, systems and cells comprising chimeric antigen receptors (CARs), synthetic immune receptors (SIRs), and the like in combination the specific activators of NFkB activity, thus improving cellular proliferation, expression and reduced apoptosis, which improves cell persistence in adoptive cell therapy.
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