Method for estimating the effectiveness against rheumatoid arthritis of a co-stimulation modulator of T-lymphocytes

摘要

The present invention concerns a method for estimating the effectiveness of treatment by a modulator agent of the co-stimulation of T-lymphocytes cells in a patient with rheumatoid arthritis and who has had inadequate response to at least one prior biotherapy, consisting of analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said agent is a treatment which will engender a beneficial response for said patient. The present invention also concerns a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data concerning the expression of said biomarkers and means for processing these data, configured to estimate the effectiveness of said treatment in the patient. The biomarkers include at least two biomarkers chosen from the group consisting of C4b-Binding Protein (C4BP), C-Reactive Protein (CRP), Cartilage Oligomeric Matrix Protein (COMP), Fibronectine (FN) and Lipopolysaccharide-Binding Protein (LBP).