Use of Lactobacillus brevis ProGA28 and its metabolites in the treatment or improvement of sleep disorders

摘要

#$%^&*AU2019101449A420200116.pdf#####ABSTRACT OF THE DISCLOSURE The present invention discloses novel Lactobacillus brevis ProGA28, deposited May 28, 2019, in German Collection of Microorganisms and Cell Cultures under 5 Accession Number DSM 33167. The metabolites of the novel Lactobacillus brevis ProGA28 have the ability to improve the sleep quality, can effectively reduce the duration of rapid eye movement sleep, reduce the number of sleeps, increase the overall sleep time and extend the time of 10 single sleep, and can increase the proportion of slow waves in brain waves during sleep, to achieve the efficacy of treating or improving sleep disorders and related complications, such as anxiety and immune system diseases. 15