TILIANIN LOADED OXIDATION RESPONSE NANO-MICELLE AND PREPARATION METHOD THEREFOR

摘要

#$%^&*AU2019101709A420200213.pdf#####ABSTRACT The present invention discloses a tilianin loaded oxidation response nano-micelle and a preparation method therefor. The tilianin loaded oxidation response nanomicelle is prepared from 0.1 part to 0.5 part of tilianin, 1 part to 15 parts of amphiphilic poly(propylene sulfide)-co-poly(ethylene glycol) copolymer (PPS-PEG copolymer for short) carrier material, 0.02 part to 0.05 part of organic solvent and 1 part to 15 parts of ultra-pure water (UP water for short). The tilianin loaded oxidation response nano-micelle and the preparation method therefor in the present invention have small particle diameter which is 60nm to 130nm. In the tilianin loaded oxidation response nano-micelle of the present invention, the PPS-PEG copolymer carrier material can cooperate with the tilianin to perform the role of anti-oxidative stress. 191614 -12 - ---- Tilianin loaded micellso 10/ C,) C 8 64/ 2/ 0 - .... - -.-....... .... ...... ----- 11) 1000 10000 Diameter (nm) Fig. 1 Zeta Potential Distrbuton -100 0 100 Apparent Zeta Potential (mV) Fig. 2 Fig. 3 1/2