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MELANOMA CANINE VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
MELANOMA CANINE VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
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机译:黑色素犬犬疫苗组合物及其使用方法
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摘要
The present invention relates to compositions and methods for generating a nucleic acid delivery system comprising a nucleic acid sequence encoding a heterologous protein comprising a canine tumor-specific antigen (canine melanoma polyepitope (K9Melapoly)) and an inhibitor of an immuno-inhibitory pathway (HSV-1 gD). Additionally, the current invention includes compositions and methods of treating of and/or preventing or immunizing a canine against melanoma, and methods of inducing an effector and memory T cell immune response in a canine administered the nucleic acid delivery system of the invention. Furthermore, the invention encompasses a pharmaceutical composition for vaccinating a canine as well as a protein expression system.
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