Diffusion monitoring protocol for optimized tissue fixation

摘要

#$%^&*AU2019202839B220200702.pdf#####ABSTRACT The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-offlight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative. [Fig. 1] P264023D1 22577420 11/13 102 ACOUSTIC MONITORING DEVICE ) 0 110 ---- ------- -1o r112 111 DIFFUSION - FIXATION MONITORING 114 11314 QUALITY CORRELATION DATABASE 105 PROCESSOR 101 FIG. 1