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APPLICATION OF LITHIUM 4-METHOXYANILINE IN CATALYSIS OF HYDROBORATION REACTION OF IMINE AND BORANE
APPLICATION OF LITHIUM 4-METHOXYANILINE IN CATALYSIS OF HYDROBORATION REACTION OF IMINE AND BORANE
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机译:4-甲氧基苯胺锂在亚胺与硼烷加氢反应中的应用
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摘要
The present invention relates to the application of lithium 4-methoxyaniline, and in particular to the application of lithium 4-methoxyaniline in catalysis of the hydroboration reaction of an imine and a borane. A catalyst, a borane and an imine are successively stirred and mixed until uniform, reacted for 1 to 2 hours, and then exposed to air so as to stop the reaction, and the reaction liquid is subjected to decompression to remove a solvent therein, so as to obtain a borate with different substituents. The lithium 4-methoxyaniline disclosed in the present invention can catalyze the hydroboration reaction of an imine and a borane in a high activity manner at room temperature, wherein the amount of the catalyst is merely 4-5 mol% of the molar amount of the imine, and the yield of the reaction can reach 90% or more. The yield of a borate with different substituents can reach 99% with mild reaction conditions under an optimized condition by using simple lithium 4-methoxyaniline, compared to an existing catalyst system.
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