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TREATMENT AND PREVENTION OF MALARIA BASED ON THE ANTIGEN PFRH5 AND ANTIBODIES AGAINST THE SAME

机译：基于PFRH5抗原和抗疟疾的疟疾的治疗和预防

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摘要

There are provided antibodies and combination thereof, and other binding proteins against malarial antigens, as well as said antigens and vectors encoding the antibodies and antigens. The invention also provides the use of such compounds and combinations thereof in the prevention or treatment of malaria. In particular, synergistic combinations of non-neutralising antibodies directed towards an epitope on Reticulocyte-binding protein Homologue (PfRH5) and neutralising antibodies directed towards Plasmodium merozoite antigens are provided.

机译：提供了抗体及其组合，以及针对疟疾抗原的其他结合蛋白，以及所述抗原和编码该抗体和抗原的载体。本发明还提供了此类化合物及其组合在预防或治疗疟疾中的用途。特别是，提供了针对网织细胞结合蛋白同源物（PfRH5）的表位的非中和抗体与针对疟原虫裂殖子抗原的中和抗体的协同组合。 展开▼

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公开/公告号WO2020074908A3

专利类型

公开/公告日2020-05-22

原文格式PDF

申请/专利权人 OXFORD UNIVERSITY INNOVATION LIMITED;
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申请/专利号WO2019GB52885

发明设计人 DRAPER SIMON;HIGGINS MATTHEW;ALANINE DANIEL G. W.;
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申请日2019-10-10

分类号A61K39/015;C07K16/20;

国家 WO

入库时间 2022-08-21 11:11:56

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1. 治疗疟疾和预防疟疾传播的化合物 [P] . 中国专利： CN102595894A . 2012-07-18

2. 共有抗原构建体和由其制备的疫苗以及使用所述疫苗治疗疟疾的方法 [P] . 中国专利： CN110195069A . 2019-09-03

3. TREATMENT AND PREVENTION OF MALARIA BASED ON THE ANTIGEN PFRH5 AND ANTIBODIES AGAINST THE SAME [P] . EP3863666A2 . 2021-08-18

机译：基于抗原PFRH5和抗体的疟疾治疗和预防相同的抗体

4. PFRH5 DERIVED ANTIGEN FOR TREATMENT OF MALARIA [P] . 欧洲知识产权局专利： EP3209325A2 . 2017-08-30

机译： PFRH5抗原治疗疟疾

5. PFRH5 DERIVED ANTIGEN FOR TREATMENT OF MALARIA [P] . 世界知识产权组织专利： WO2016016651A3 . 2016-04-28

机译： PFRH5抗原治疗疟疾

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