首页> 外国专利> BIOMARKER OF CHRONIC KIDNEY DISEASE IN LIVER TRANSPLANT RECIPIENTS

BIOMARKER OF CHRONIC KIDNEY DISEASE IN LIVER TRANSPLANT RECIPIENTS

机译:肝移植患者中慢性肾脏疾病的生物标志物

摘要

Disclosed are methods for predicting, inhibiting, and treating chronic kidney disease (CKD) in a subject that that is preparing to undergo a liver transplant. The methods may include detecting a protein biomarker in a serum sample from the subject prior to the subject being administered a liver transplant procedure and/or after the subject has been administered the liver transplant procedure. Suitable protein markers for the disclosed methods may include but are not limited to osteopontin (OPN) and/or tissue inhibitor of metalloproteases 1 (TIMP1).
机译:公开了用于预测,抑制和治疗准备进行肝移植的受试者中的慢性肾脏疾病(CKD)的方法。该方法可以包括在受试者进行肝移植手术之前和/或在受试者进行肝移植手术之后,从受试者的血清样品中检测蛋白质生物标志物。用于公开的方法的合适的蛋白质标记物可以包括但不限于骨桥蛋白(OPN)和/或金属蛋白酶1的组织抑制剂(TIMP1)。

著录项

  • 公开/公告号WO2020077267A1

    专利类型

  • 公开/公告日2020-04-16

    原文格式PDF

  • 申请/专利权人 NORTHWESTERN UNIVERSITY;

    申请/专利号WO2019US55942

  • 发明设计人 LEVITSKY JOSH;ABECASSIS MICHAEL M.;

    申请日2019-10-11

  • 分类号G01N33/49;G01N33/53;G01N33/70;C07K14/47;A61P13/12;

  • 国家 WO

  • 入库时间 2022-08-21 11:11:56

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