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TENIPOSIDE INJECTION SOLUTION HAVING GOOD DILUTION STABILITY AND PREPARATION METHOD THEREFOR
TENIPOSIDE INJECTION SOLUTION HAVING GOOD DILUTION STABILITY AND PREPARATION METHOD THEREFOR
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机译:具有良好稀释稳定性的替尼替斯注射液及其制备方法
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摘要
Disclosed by the present invention are a teniposide injection solution having good dilution stability and a preparation method therefor. A teniposide injection solution or powder, comprising teniposide, cyclodextrin, a stabilizer and an additive; the mass ratio of teniposide: cyclodextrin is 1: 5-20. Compared with a commercially available teniposide injection (VUMON), the teniposide preparation of the present invention does not contain polyoxyethylene castor oil, benzoic acid and N, N-dimethylacetamide, has fewer harmful side effects, reduces adverse reactions in patients, and facilitates good patient compliance. The teniposide preparation of the present invention has excellent dilution stability, no dilution or precipitation occurs during a dilution process, and the preparation may be stably stored for 12 hours without precipitation when diluted to the final concentration; meanwhile, the preparation process is simple and costs are low.
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