NON-INVASIVE URINARY BIOMARKERS FOR THE DETECTION OF UROTHELIAL CARCINOMA OF THE BLADDER

摘要

The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for detecting urothelial carcinomas. In one embodiment, a method comprises the step of detecting CD24, CD49f and NANOG in a urine sample obtained from a patient suspected of having urothelial carcinoma. In a specific embodiment, the detection step comprises polymerase chain reaction (PCR). In certain embodiment, the PCR step utilizes at least one primer comprising SEQ ID NOS: 1, 2, 23, 24, 13 and 14. In another embodiment, the method further comprises treating the patient with one or more of surgery, radiation therapy, chemotherapy and immunotherapy.