Heteroaryl pyridone and aza-pyridone compounds as inhibitors of Btk activity

摘要

#$%^&*AU2020202707A120200514.pdf#####ABSTRACT Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X2, and X3 are N, and including stereoisomers, tautomers, and 5 pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. R5 NH R4 y2 O RN N RT Y1 R6 X 1 x3 X2' 0