Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

摘要

#$%^&*AU2020203424A120200611.pdf#####ABSTRACT The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (AP) peptides including blocking the accumulation of extracellular AP oligomers, inhibiting Ap-mediated oxygenase activity, reducing Ap-induced mitochondrial dysfunction and/or preventing Ap-induced neuronal apoptosis.