METHODS AND GENOMIC CLASSIFIERS FOR PROGNOSIS OF BREAST CANCER AND PREDICTING BENEFIT FROM ADJUVANT RADIOTHERAPY

摘要

Methods, systems, and kits for the diagnosis, prognosis, and treatment of breast cancer in a subject are disclosed. The invention also provides biomarkers and clinically useful genomic classifiers for identifying subjects at low risk of breast cancer recurrence who are likely to benefit from adjuvant radiotherapy. Further disclosed herein, in certain instances, are probe sets for use in detecting such biomarkers for determining the risk of breast cancer recurrence in a subject (e.g., locoregional recurrence). Methods of beating breast cancer based on expression profiling to determine the risk of breast cancer recurrence are also provided.