Disclosed in the present invention are a tumor-related sequence, a long-chain non-coding RNA (lncRNA) and use thereof. lncRNA GMAN is relatively highly expressed in gastric cancer, and especially, is significantly highly expressed in a sample of a gastric cancer patient, which generates distant metastasis, in M1 stage. The high expression of GMAN is significantly related to the poor prognosis of the gastric cancer patient. Studies show that GMAN plays an important role in the development of gastric cancer, GMAN being capable of significantly promoting invasion and metastasis of gastric cancer cells. Further studies show that MFR segment of GMAN is critical to the function of the GMAN. Treatment experiments using CRISPR/Cas9 show that GMAN, particularly MFR segments of GMAN, can effectively inhibit metastasis of gastric cancer, and can serve as a new strategy for clinically controlling tumor metastasis.
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