METHOD FOR PRODUCING KIDNEY STRUCTURE HAVING DENDRITICALLY BRANCHED COLLECTING DUCT FROM PLURIPOTENT STEM CELLS

摘要

The purpose of the present invention is to provide, inter alia, a method for producing ureteric bud cells from pluripotent stem cells in vitro. More specifically, the purpose of the present invention is to provide a method for producing ureteric bud cells and WD progenitor-like cells that are a progenitor of the ureteric bud cells. Provided are a method for producing Wolffian duct (WD) progenitor-like cells that includes step A: a step for obtaining C-X-C chemokine receptor 4 (Cxcr4)+ and KIT proto-oncogene receptor tyrosine kinase (KIT)+ cells, a method for producing ureteric-bud-like cells using WD progenitor cells that are Cxcr4+ and KIT+, and a method for producing kidney organoids in which the ureteric-bud-like cells are used.