ANGPTL4 OLIGONUCLEOTIDES INFLUENCING THE REGULATION OF THE FATTY ACID METABOLISM

摘要

The present invention refers to an ANGPTL4 inhibitor consisting of an oligonucleotide comprising 12 to 22 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of ANGPTL4 of SEQ ID NO.1 (human), ANGPTL4 of SEQ ID NO. 2 (human), ANGPTL4 of SEQ ID NO.58 (mouse) and/or ANGPTL4 of SEQ ID NO.59 (mouse), wherein the oligonucleotide inhibits the expression of ANGPTL4, and a pharmaceutical composition comprising such inhibitor and a pharmaceutically acceptable carrier, excipient, dilutant or a combination thereof.