METHOD FOR TRANSFERRING A RADIOISOTOPE BETWEEN TWO STATIONARY PHASES CONTAINED IN TWO CHROMATOGRAPHY COLUMNS

摘要

The invention relates to a method for transferring a radioisotope that is attached to a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, in order to fix the radioisotope to the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium. Said method comprises at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 is obtained which comprises complexes of the radioisotope; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) carrying out at least one washing of the second stationary phase with an aqueous solution A4.