EXOSOME LOADED THERAPEUTICS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS, DIABETES MELLITUS TYPE 1 AND TYPE 2, ATHEROSCLEROTIC CARDIOVASCULAR DISEASE, AND ALPHA 1 ANTITRYPSIN DEFICIENCY

摘要

A composition for delivering a cargo to the cytoplasm of a cell, wherein the cargo treats Non-Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus Type 1 and Type 2, Atherosclerotic Cardiovascular Disease, and Alpha 1 Antitrypsin Deficiency. In another embodiment, the composition comprises: an exosome; cargo located inside the exosome, wherein the cargo comprises short interference RNA (siRNA) that depletes sodium-glucose linked transporter active sites. In another embodiment, the composition comprises: an exosome; cargo location inside the exosome, wherein the cargo corrects the missense SERPINA1 mutation from 'Z' to 'M'.