COMBINATORIAL ORAL TREATMENT OF METABOLIC DISORDERS THROUGH ORCHESTRATED RELEASE OF ENTEROKINES

摘要

The present invention relates to pharmaceutical packages comprising at least two different pharmaceutical oral dosage forms each containing a core and an enteric coating, the cores each containing at least one compound stimulating enteroendocrine cells to release at least one enterokine and a disintegrant leading to a burst release of the core when the respective enteric coating is substantially dissolved and/or degraded, wherein each of the pharmaceutical oral dosage forms exhibit a burst release of the respective core in different parts of the small intestine of a subject and/or the dosage forms exhibit different travelling times through the small intestine of the subject. The active compounds of such combination of oral dosage forms can be the same or different in each of the dosage forms. The present combination of pharmaceutical oral dosage form are used for prevention and/or treatment of disorders and conditions relating to the energy household of and metabolism in the, preferably human, body, but also conditions or disorders being the consequence of or relating to, respectively, malfunction of energy household and metabolism.