TREATMENT OF GASTROINTESTINAL DISORDERS AND SYMPTOMS THEREOF

摘要

Methods of reducing inflammation and chronic pain in the gut of a subject suffering from inflammatory bowel diseas (IBD) are disclosed herein. Particularly disclosed are methods of administrating the apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE1/Ref-1) inhibitor, APX3330, which blocks APE1 and regulates transcription factors (TFs) involved in inflammation, thereby alleviating inflammatory or chronic pain.